JOHN White and Simeon Akinola has both suffered injury setbacks, according to Southend United chairman Ron Martin.
White has missed the last two games with a hamstring injury while Akinola, who signed last week, is working his way back to full fitness after not having much of a pre-season.
But the duo now seem unlikely to feature against Morecambe this weekend.
"John White pulled up in training today and Simeon has a little twinge too," Martin told BBC Essex.
"Simeon pulled up at the end of training with a potential quad injury we don’t want to see that because we think he can be a big player for us.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here