Rafael Nadal stayed on course for a sixth Madrid Open title after reaching the quarter-finals with victory over Alexei Popyrin.

After defeating Spanish heir apparent Carlos Alcaraz on Wednesday, Nadal took on another young gun in Australian Popyrin, who had upset Jannik Sinner in the second round.

Popyrin won the first seven points of the match but was unable to find the consistency needed to really trouble Nadal and the top seed eased to a 6-3 6-3 victory.

Nadal has not been as dominant in Madrid as the other big clay tournaments, with the altitude less favourable to his style of play, but he remains the clear favourite.

The 34-year-old said: “Today it’s true that there is a lot of young, good players. It’s something normal that is happening. I’m excited that at my age I am able to keep playing against all of them. They are good. They are talented. They have a
great future.”

Nadal will face 2018 winner Alexander Zverev, who beat Britain’s Dan Evans 6-3 7-6 (3), in the last eight.

Second seed Daniil Medvedev fell to a 6-4 6-7 (2) 6-1 loss against Cristian Garin. The Russian, an avowed hater of clay, needed treatment for a nosebleed and was given a warning for arguing with a spectator in the stands.

Stefanos Tsitsipas was another high-profile casualty, the Greek fourth seed losing 7-6 (4) 6-4 to Norwegian Casper Ruud.

Third seed Dominic Thiem continues to look refreshed after more than a month out, with the Austrian seeing off Alex De Minaur 7-6 (7) 6-4, saving a set point in the opener.

Dominic Thiem hits a forehand against Alex De Minaur
Dominic Thiem hits a forehand against Alex De Minaur (Bernat Armangue/AP)

“For me it was perfect because obviously he’s first of all a top player and second of all he also likes to play longer rallies,” said Thiem.

“There were some good, long rallies. I was many, many times out of breath. It was perfect for me to get back a little bit the match rhythm, to run down a lot of balls.”

Thiem will next face John Isner, who continued his strong week with a 7-6 (4) 3-6 7-6 (4) victory over sixth seed Andrey Rublev.

Kazakh Alexander Bublik added another notable victory in 2021 by taking out Australian Open semi-finalist Aslan Karatsev 6-4 6-3.